2. Academic Validation
  3. An overview of the serpin superfamily

An overview of the serpin superfamily

  • Genome Biol. 2006;7(5):216. doi: 10.1186/gb-2006-7-5-216.
Ruby H P Law 1,  Qingwei Zhang,  Sheena McGowan,  Ashley M Buckle,  Gary A Silverman,  Wilson Wong,  Carlos J Rosado,  Chris G Langendorf,  Rob N Pike,  Philip I Bird,  James C Whisstock
Affiliations

Affiliation

  • 1 Department of Biochemistry and Molecular Biology, Monash University, Clayton Campus, Melbourne VIC 3800, Australia.
PMID: 16737556 DOI: 10.1186/gb-2006-7-5-216
Abstract

Serpins are a broadly distributed family of Protease Inhibitors that use a conformational change to inhibit target Enzymes. They are central in controlling many important proteolytic cascades, including the mammalian coagulation pathways. Serpins are conformationally labile and many of the disease-linked mutations of serpins result in misfolding or in pathogenic, inactive Polymers.

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