2. Academic Validation
  3. Indenone derivatives: a novel template for peroxisome proliferator-activated receptor gamma (PPARgamma) agonists

Indenone derivatives: a novel template for peroxisome proliferator-activated receptor gamma (PPARgamma) agonists

  • J Med Chem. 2006 Jul 27;49(15):4781-4. doi: 10.1021/jm060389m.
Jin Hee Ahn 1,  Mi Sik Shin,  Sun Ho Jung,  Seung Kyu Kang,  Kwang Rok Kim,  Sang Dal Rhee,  Won Hoon Jung,  Sung Don Yang,  Seung Jun Kim,  Joo Rang Woo,  Jeong Hyung Lee,  Hyae Gyeong Cheon,  Sung Soo Kim
Affiliations

Affiliation

  • 1 Bioorganic Science Division, Korea Research Institute of Chemical Technology, Yuseong-Gu, Daejeon, 305-600, Republic of Korea.
PMID: 16854085 DOI: 10.1021/jm060389m
Abstract

Agonists of Peroxisome Proliferator-activated Receptor gamma (PPAR gamma) are of interest as a treatment for diabetes, which prompted the identification of a new class of non-TZD PPAR gamma agonist. Moreover, compound 14c has displayed the most active agonistic activity with an EC50 value of 50 nM, in addition to exhibiting a new binding mode in the X-ray cocrystal structure.

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