2. Academic Validation
  3. Human IRGM induces autophagy to eliminate intracellular mycobacteria

Human IRGM induces autophagy to eliminate intracellular mycobacteria

  • Science. 2006 Sep 8;313(5792):1438-41. doi: 10.1126/science.1129577.
Sudha B Singh 1,  Alexander S Davis,  Gregory A Taylor,  Vojo Deretic
Affiliations

Affiliation

  • 1 Department of Molecular Genetics and Microbiology, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
PMID: 16888103 DOI: 10.1126/science.1129577
Abstract

Immunity-related p47 guanosine triphosphatases (IRG) play a role in defense against intracellular pathogens. We found that the murine Irgm1 (LRG-47) guanosine triphosphatase induced Autophagy and generated large autolysosomal organelles as a mechanism for the elimination of intracellular Mycobacterium tuberculosis. We also identified a function for a human IRG protein in the control of intracellular pathogens and report that the human Irgm1 ortholog, IRGM, plays a role in Autophagy and in the reduction of intracellular bacillary load.

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