2. Academic Validation
  3. Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains

Synthesis of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones as potent antimalarial agents active against CQ-resistant P. falciparum strains

  • Bioorg Med Chem Lett. 2006 Oct 15;16(20):5384-8. doi: 10.1016/j.bmcl.2006.07.060.
Sandra Gemma 1,  Gagan Kukreja,  Caterina Fattorusso,  Marco Persico,  Maria P Romano,  Maria Altarelli,  Luisa Savini,  Giuseppe Campiani,  Ernesto Fattorusso,  Nicoletta Basilico,  Donatella Taramelli,  Vanessa Yardley,  Stefania Butini
Affiliations

Affiliation

  • 1 Dipartimento Farmaco Chimico Tecnologico, Università di Siena, via Aldo Moro, 53100 Siena, Italy.
PMID: 16890433 DOI: 10.1016/j.bmcl.2006.07.060
Abstract

A series of N1-arylidene-N2-quinolyl- and N2-acrydinylhydrazones were synthesized and tested for their antimalarial properties. These compounds showed remarkable anti-plasmodial activity in vitro especially against chloroquine-resistant strains. Their potent biological activity makes them promising lead structures for the development of new antimalarial drugs.

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