2. Academic Validation
  3. Synthesis and cytotoxicities of dioscin derivatives with decorated chacotriosyl residues

Synthesis and cytotoxicities of dioscin derivatives with decorated chacotriosyl residues

  • Bioorg Med Chem Lett. 2006 Nov 1;16(21):5629-32. doi: 10.1016/j.bmcl.2006.08.019.
Shilei Zhu 1,  Yichun Zhang,  Ming Li,  Jia Yu,  Lihong Zhang,  Yingxia Li,  Biao Yu
Affiliations

Affiliation

  • 1 State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
PMID: 16905317 DOI: 10.1016/j.bmcl.2006.08.019
Abstract

Two series of dioscin derivatives (4a-o and 5a-o) with selected modifications at the 6' and 4''' positions of the chacotriosyl residue, respectively, were synthesized. All the 6'-N-acyl-dioscin derivatives did not show considerable inhibitory activities at 10 microM, while most of the 4'''-O-(2-N-acyl)ethyl-dioscin derivatives behaved as potent as dioscin, against the growth of tumor cells.

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