2. Academic Validation
  3. Steroidal saponins from Solanum nigrum

Steroidal saponins from Solanum nigrum

  • J Nat Prod. 2006 Aug;69(8):1158-63. doi: 10.1021/np060091z.
Xinlan Zhou 1,  Xiangjiu He,  Guanghui Wang,  Hao Gao,  Guangxiong Zhou,  Wencai Ye,  Xinsheng Yao
Affiliations

Affiliation

  • 1 Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang, 110016, People's Republic of China.
PMID: 16933867 DOI: 10.1021/np060091z
Abstract

Six new steroidal saponins, solanigrosides C-H (2-7), and one known saponin, degalactotigonin (1), were isolated from the whole plant of Solanum nigrum. Their chemical structures were elucidated using spectroscopic analysis, chemical degradation, and derivatization. All seven compounds were tested for their cytotoxicity using four human tumor cell lines (HepG2, NCI-H460, MCF-7, SF-268). Only compound 1 was cytotoxic, with IC50 values of 0.25-4.49 microM.

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