2. Academic Validation
  3. Chronic treatment with talipexole dihydrochloride on abnormal involuntary movement in humans

Chronic treatment with talipexole dihydrochloride on abnormal involuntary movement in humans

  • Clin Neuropharmacol. 1990 Jun;13(3):259-63. doi: 10.1097/00002826-199006000-00010.
T Nishikawa 1,  S Yamada,  A Tsuda,  M Tanaka,  I Koga,  Y Uchida
Affiliations

Affiliation

  • 1 Department of Pharmacology, Kurume University School of Medicine, Japan.
PMID: 1694103 DOI: 10.1097/00002826-199006000-00010
Abstract

Two cases of severe dystonia and dyskinesia were treated with talipexole, a dopamine autoreceptor agonist, and the metabolites of dopamine, norepinephrine, and serotonin in cerebrospinal fluid (CSF) were determined. Despite significant reductions in these metabolites in CSF, behavioral amelioration of these cases could not be observed. The present findings argue for further studies to explore the clinical usefulness of dopaminergic agonists such as talipexole.

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