2. Academic Validation
  3. Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis

Stroma-derived factor (SDF-1/CXCL12) and human tumor pathogenesis

  • Am J Physiol Cell Physiol. 2007 Mar;292(3):C987-95. doi: 10.1152/ajpcell.00406.2006.
Ilona Kryczek 1,  Shuang Wei,  Evan Keller,  Rebecca Liu,  Weiping Zou
Affiliations

Affiliation

  • 1 Department of Surgery, University of Michigan School of Medicine, Ann Arbor, MI 48109-0669, USA.
PMID: 16943240 DOI: 10.1152/ajpcell.00406.2006
Abstract

The chemokine stroma-derived factor (SDF-1/CXCL12) plays multiple roles in tumor pathogenesis. It has been demonstrated that CXCL12 promotes tumor growth and malignancy, enhances tumor angiogenesis, participates in tumor metastasis, and contributes to immunosuppressive networks within the tumor microenvironment. Therefore, it stands to reason that the CXCL12/CXCR4 pathway is an important target for the development of novel anti-cancer therapies. In this review, we consider the pathological nature and characteristics of the CXCL12/CXCR4 pathway in the tumor microenvironment. Strategies for therapeutically targeting the CXCL12/CXCR4 axis also are discussed.

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