2. Academic Validation
  3. 2,6-Quinolinyl derivatives as potent VLA-4 antagonists

2,6-Quinolinyl derivatives as potent VLA-4 antagonists

  • Bioorg Med Chem Lett. 2007 Jan 1;17(1):142-6. doi: 10.1016/j.bmcl.2006.09.069.
Marie-Agnès Lassoie 1,  Fabienne Broeders,  Philippe Collart,  Laurent Defrère,  Françoise de Laveleye-Defais,  Thierry Demaude,  Abdoulaye Gassama,  Gérald Guillaumet,  Jean-Claude Hayez,  Laszlo Kiss,  Laurent Knerr,  Jean-Marie Nicolas,  Stéphanie Norsikian,  Luc Quéré,  Sylvain Routier,  Valérie Verbois,  Laurent Provins
Affiliations

Affiliation

  • 1 UCB S.A., R&D, Chemin du Foriest, B-1420 Braine-l'Alleud, Belgium.
PMID: 17035017 DOI: 10.1016/j.bmcl.2006.09.069
Abstract

A new series of 2,6-quinolinyl derivatives was prepared leading to potent low nanomolar VLA-4/VCAM-1 antagonists.

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