2. Academic Validation
  3. 4-Aminopyrimidines as novel HIV-1 inhibitors

4-Aminopyrimidines as novel HIV-1 inhibitors

  • Bioorg Med Chem Lett. 2007 Jan 1;17(1):260-5. doi: 10.1016/j.bmcl.2006.09.047.
Venkat R Gadhachanda 1,  Baogen Wu,  Zhiwei Wang,  Kelli L Kuhen,  Jeremy Caldwell,  Helmut Zondler,  Harald Walter,  Mark Havenhand,  Yun He
Affiliations

Affiliation

  • 1 Genomics Institute of the Novartis Research Foundation (GNF), 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.
PMID: 17035019 DOI: 10.1016/j.bmcl.2006.09.047
Abstract

A series of 4-aminopyrimidines (1) was identified as novel HIV inhibitors of unknown molecular target. Structural modifications were carried out to establish its SAR and identify the linking site for target identification. A number of analogs were found to possess single digit inhibitory activity for HIV replication. Several analogs with various potential linkers, including a biotinated analog, also exhibited excellent potency, and could serve as tools for the identification of novel anti-HIV targets.

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