HTRA1 promoter polymorphism in wet age-related macular degeneration

Science. 2006 Nov 10;314(5801):989-92. doi: 10.1126/science.1133807.

Andrew Dewan ¹, Mugen Liu, Stephen Hartman, Samuel Shao-Min Zhang, David T L Liu, Connie Zhao, Pancy O S Tam, Wai Man Chan, Dennis S C Lam, Michael Snyder, Colin Barnstable, Chi Pui Pang, Josephine Hoh

Affiliations

Affiliation

1 Department of Epidemiology and Public Health, Yale University, 60 College Street, New Haven, CT 06520, USA.

PMID: 17053108 DOI: 10.1126/science.1133807

Abstract

Age-related macular degeneration (AMD), the most common cause of irreversible vision loss in individuals aged older than 50 years, is classified as either wet (neovascular) or dry (nonneovascular). Inherited variation in the complement Factor H gene is a major risk factor for drusen in dry AMD. Here we report that a single-nucleotide polymorphism in the promoter region of HTRA1, a serine Protease gene on chromosome 10q26, is a major genetic risk factor for wet AMD. A whole-genome association mapping strategy was applied to a Chinese population, yielding a P value of <10(-11). Individuals with the risk-associated genotype were estimated to have a likelihood of developing wet AMD 10 times that of individuals with the wild-type genotype.

Name
Email *

	Sorry, but the email address you supplied was invalid.