Bioactive guaianolides from siyekucai (Ixeris chinensis)

J Nat Prod. 2006 Oct;69(10):1425-8. doi: 10.1021/np068015j.

Shujun Zhang ¹, Ming Zhao, Liming Bai, Toshiaki Hasegawa, Jinlan Wang, Liyan Wang, Hongyan Xue, Qigang Deng, Fenglan Xing, Yuhua Bai, Jun-ichi Sakai, Jiao Bai, Rei Koyanagi, Yoshinori Tsukumo, Takao Kataoka, Kazuo Nagai, Katutoshi Hirose, Masayoshi Ando

Affiliations

Affiliation

1 Graduate School of Science and Technology and Department of Chemistry and Chemical Engineering, Niigata University, Ikarashi, 2-8050, Niigata, 950-2181, Japan.

PMID: 17067155 DOI: 10.1021/np068015j

Abstract

Two new guaianolides, named chinensiolides D (5) and E (6), were isolated from Ixeris chinensis Nakai, and their structures were determined to be 10alpha-hydroxy-3-oxoguaia-11(13)-eno-12,6alpha-lactone (5) and 10alpha-hydroxy-3beta-O-[2,6-di(p-hydroxyphenylacetyl)-beta-glucopylanosyl]guaia-4(15),11(13)-dieno-12,6alpha-lactone (6). The first isolation of (11S)-10alpha-hydroxy-3-oxoguaia-4-eno-12,6alpha-lactone (4) from natural sources and its characterization are also reported. Chinenciolide E (6) showed significant growth inhibitory activity toward VA-13 malignant lung tumor cells (IC50 = 0.72 microM).

Name
Email *

	Sorry, but the email address you supplied was invalid.