2. Academic Validation
  3. Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors

Constrained azacyclic analogues of the immunomodulatory agent FTY720 as molecular probes for sphingosine 1-phosphate receptors

  • Bioorg Med Chem Lett. 2007 Jan 15;17(2):491-4. doi: 10.1016/j.bmcl.2006.10.014.
Stephen Hanessian 1,  Guillaume Charron,  Andreas Billich,  Danilo Guerini
Affiliations

Affiliation

  • 1 Department of Chemistry, Université de Montréal, PO Box 6128, Station Centre-ville, Montréal, Que., Canada H3C 3J7. stephen.hanessian@umontreal.ca
PMID: 17070046 DOI: 10.1016/j.bmcl.2006.10.014
Abstract

Constrained azacyclic analogues of FTY720 were prepared starting with d- and l-pyroglutamic acids. One enantiomer was shown to be a substrate for sphingosine kinase 2, being phosphorylated 4-fold more efficiently than FTY720. Among the corresponding phosphates, two were found to have unusual specificity in binding to S1P receptors: while being inactive on S1P1 and S1P3, they acted as potent agonists on S1P4 and S1P5. The phosphates may be useful to explore the biology and binding site of these receptors.

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