2. Academic Validation
  3. Synthesis of carbon-11 labeled sulfonanilide analogues as new potential PET agents for imaging of aromatase in breast cancer

Synthesis of carbon-11 labeled sulfonanilide analogues as new potential PET agents for imaging of aromatase in breast cancer

  • Bioorg Med Chem Lett. 2007 Jan 15;17(2):332-6. doi: 10.1016/j.bmcl.2006.10.065.
Min Wang 1,  Gabrielle Lacy,  Mingzhang Gao,  Kathy D Miller,  George W Sledge,  Qi-Huang Zheng
Affiliations

Affiliation

  • 1 Department of Radiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
PMID: 17095221 DOI: 10.1016/j.bmcl.2006.10.065
Abstract

Aromatase is a particularly good target in the treatment of Estrogen Receptor positive breast Cancer. Novel carbon-11 labeled sulfonanilide analogues, N-[11C]methyl-N-(2-alkyloxy-4-nitrophenyl)-methanesulfonamides ([11C]3a-f, alkyl=propyl, isopropyl, 1-ethyl-propyl, cyclopentyl, cyclohexyl, and cyclohexylethyl), were designed and synthesized as potential PET agents for imaging of aromatase in breast Cancer.

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