2. Academic Validation
  3. C35 terpenoids from the bark of Calocedrus macrolepis var. formosana with activity against human cancer cell lines

C35 terpenoids from the bark of Calocedrus macrolepis var. formosana with activity against human cancer cell lines

  • J Nat Prod. 2006 Nov;69(11):1611-3. doi: 10.1021/np0600550.
Chin-Lin Hsieh 1,  Mei-Huims Tseng,  Yi-Yuan Shao,  Jang-Yang Chang,  Ching-Chuan Kuo,  Chi-Yen Chang,  Yueh-Hsiung Kuo
Affiliations

Affiliation

  • 1 Department of Chemistry, National Taiwan University, Taipei, Taiwan 106.
PMID: 17125231 DOI: 10.1021/np0600550
Abstract

Ferrugicadinol (1) and ferrugieudesmol (2), two new compounds with a unique C35 terpene skeleton, were isolated from the bark of Calocedrus macrolepis var. formosana. Their structures were elucidated principally from spectroscopic evidence. The two new C35 terpenes showed cytotoxicity against human oral epidermoid carcinoma KB cells with IC50 values ranging from 11 to 14 microM.

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