2. Academic Validation
  3. Acylphloroglucinol derivatives from Hypericum prolificum

Acylphloroglucinol derivatives from Hypericum prolificum

  • J Nat Prod. 2006 Nov;69(11):1645-8. doi: 10.1021/np060356+.
Geneive E Henry 1,  Smita Raithore,  Yanjun Zhang,  Bolleddula Jayaprakasam,  Muraleedharan G Nair,  David Heber,  Navindra P Seeram
Affiliations

Affiliation

  • 1 Department of Chemistry, Susquehanna University, 514 University Avenue, Selinsgrove, Pennsylvania 17870, USA. henry@susqu.edu
PMID: 17125240 DOI: 10.1021/np060356+
Abstract

Three new acylphloroglucinol derivatives have been isolated from the hexane extract of the aerial parts of Hypericum prolificum L.: prolificin A (1), prolifenone A (2), and prolifenone B (3). The structures were elucidated on the basis of extensive 2D NMR and MS data. All three compounds were evaluated for in vitro cell proliferation inhibitory activity against human breast (MCF-7), lung (NCI-H460), CNS (SF-268), stomach (AGS), and colon (HCT-116) tumor cell lines. Prolificin A showed growth inhibition of all cell lines with IC50 values ranging from 23 to 36 microM. Prolifenones A and B were inactive at the concentrations tested.

Figures