2. Academic Validation
  3. Design and synthesis of a novel class of dual PPARgamma/delta agonists

Design and synthesis of a novel class of dual PPARgamma/delta agonists

  • Bioorg Med Chem Lett. 2007 Feb 15;17(4):1052-5. doi: 10.1016/j.bmcl.2006.11.029.
Isabel C Gonzalez 1,  Jason Lamar,  Fatima Iradier,  Yanping Xu,  Leonard L Winneroski,  Jeremy York,  Nathan Yumibe,  Richard Zink,  Chahrzad Montrose-Rafizadeh,  Gary J Etgen,  Carol L Broderick,  Brian A Oldham,  Nathan Mantlo
Affiliations

Affiliation

  • 1 Lilly Research Laboratories, A Division of Eli Lilly & Company, Lilly Corporate center, Indianapolis, IN 46285, USA. gonzalez_isabel_c@lilly.com
PMID: 17129725 DOI: 10.1016/j.bmcl.2006.11.029
Abstract

The design and synthesis of dual PPAR gamma/delta agonist (R)-3-{2-ethyl-4-[3-(4-ethyl-2-pyridin-2-yl-phenoxy)-butoxy]-phenyl}propionic acid is described. This compound dose-dependently lowered plasma glucose in hyperglycemic male Zucker diabetic fatty (ZDF) rats and produced less weight gain relative to rosiglitazone at an equivalent level of glucose control.

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