2. Academic Validation
  3. Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa

Rotenoids and flavonoids with anti-invasion of HT1080, anti-proliferation of U937, and differentiation-inducing activity in HL-60 from Erycibe expansa

  • Bioorg Med Chem. 2007 Feb 1;15(3):1539-46. doi: 10.1016/j.bmc.2006.09.024.
Hisashi Matsuda 1,  Kazutoshi Yoshida,  Katsutoshi Miyagawa,  Yasunobu Asao,  Saya Takayama,  Souichi Nakashima,  Fengming Xu,  Masayuki Yoshikawa
Affiliations

Affiliation

  • 1 Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan.
PMID: 17158054 DOI: 10.1016/j.bmc.2006.09.024
Abstract

Principal rotenoids (deguelin, tephrosin, rotenone, and 12a-hydroxyrotenone) (3-30microM) isolated from the stems of Erycibe expansa significantly inhibited invasion of human fibrosarcoma HT1080 cells through Matrigel-coated filters and release of proMMPs-2 and 9. In addition, deguelin and tephrosin showed differentiation-inducing activity in human promyelocytic leukemia HL-60 cells. Furthermore, effects of various constituents isolated from the ethyl acetate-soluble fraction on proliferation of human leukemia U937 cells were examined. As a result, most of Isoflavones and several flavans as well as rotenoids showed moderate or substantial anti-proliferative activities.

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