2. Academic Validation
  3. Biological profile of new apoptotic agents based on 2,4-pyrido[2,3-d]pyrimidine derivatives

Biological profile of new apoptotic agents based on 2,4-pyrido[2,3-d]pyrimidine derivatives

  • Bioorg Med Chem. 2007 Feb 15;15(4):1659-69. doi: 10.1016/j.bmc.2006.12.010.
Lucía Cordeu 1,  Elena Cubedo,  Eva Bandrés,  Amaia Rebollo,  Xabi Sáenz,  Hector Chozas,  Ma Victoria Domínguez,  Mikel Echeverría,  Beatriz Mendivil,  Carmen Sanmartin,  Juan Antonio Palop,  María Font,  Jesús García-Foncillas
Affiliations

Affiliation

  • 1 Laboratorio de Farmacogenómica, Area de Oncología, Centro de Investigación Médica Aplicada, Pamplona, Spain. lcorver@alumni.unav.es
PMID: 17204425 DOI: 10.1016/j.bmc.2006.12.010
Abstract

In order to obtain less toxic antitumoral compounds we have looked for novel compounds with Anticancer activity based on proapoptotic mechanisms. The compounds studied in this work are derivatives of bicyclic aromatic systems like pyrido[2,3-d]pyrimidines. The potential antitumoral activity of the compounds was evaluated in vitro by examining their cytotoxic effects against human breast, colon, and bladder Cancer lines (MD-MBA-231, HT-29, and T-24). The data indicate that HC-6 is a potent Anticancer drug showing dose-dependent cytostatic and proapoptotic effects through activation of two different signaling pathways namely a pathway leading to cell cycle arrest and a transcription-independent route leading to rapid Apoptosis.

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