2. Academic Validation
  3. Antiviral activity of berberine and related compounds against human cytomegalovirus

Antiviral activity of berberine and related compounds against human cytomegalovirus

  • Bioorg Med Chem Lett. 2007 Mar 15;17(6):1562-4. doi: 10.1016/j.bmcl.2006.12.085.
Kyoko Hayashi 1,  Kazuki Minoda,  Yasuo Nagaoka,  Toshimitsu Hayashi,  Shinichi Uesato
Affiliations

Affiliation

  • 1 Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
PMID: 17239594 DOI: 10.1016/j.bmcl.2006.12.085
Abstract

Berberine chloride (1) and the structurally related compounds were assessed for the anti-human cytomegalovirus (HCMV) activity using the plaque assay. The anti-HCMV activity (IC(50) 0.68 microM) of 1 was equivalent to that (IC(50) 0.91 microM) of ganciclovir (GCV). The mechanism of action by which 1 inhibits the replication of HCMV is presumed to be different from that of GCV; 1 would interfere with intracellular events after virus penetration into the host cells and before viral DNA synthesis.

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