2. Academic Validation
  3. Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes

Control of human immunodeficiency virus type 1 is associated with HLA-B*13 and targeting of multiple gag-specific CD8+ T-cell epitopes

  • J Virol. 2007 Apr;81(7):3667-72. doi: 10.1128/JVI.02689-06.
Isobella Honeyborne 1,  Andrew Prendergast,  Florencia Pereyra,  Alasdair Leslie,  Hayley Crawford,  Rebecca Payne,  Shabashini Reddy,  Karen Bishop,  Eshia Moodley,  Kriebashnie Nair,  Mary van der Stok,  Noel McCarthy,  Christine M Rousseau,  Marylyn Addo,  James I Mullins,  Christian Brander,  Photini Kiepiela,  Bruce D Walker,  Philip J R Goulder
Affiliations

Affiliation

  • 1 Department of Paediatrics, Peter Medawar Building for Pathogen Research, South Parks Road, Oxford OX1 3SY, United Kingdom.
PMID: 17251285 DOI: 10.1128/JVI.02689-06
Abstract

To better understand relationships between CD8+ T-cell specificity and the immune control of human immunodeficiency virus type 1 (HIV-1), we analyzed the role of HLA-B*13, an allele associated with low viremia, in a cohort of 578 C clade-infected individuals in Durban, South Africa. Six novel B*13-restricted cytotoxic T lymphocyte epitopes were defined from analyses of 37 B*13-positive subjects, including three Gag epitopes. These B*13-restricted epitopes contribute to a broad Gag-specific CD8+ response that is associated with the control of viremia. These data are consistent with data from studies of Other HLA-class I alleles associated with HIV control that have shown that the targeting of multiple Gag epitopes is associated with relative suppression of viremia.

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