2. Academic Validation
  3. New constituents from the leaves of Morinda citrifolia

New constituents from the leaves of Morinda citrifolia

  • Chem Pharm Bull (Tokyo). 2007 Feb;55(2):343-5. doi: 10.1248/cpb.55.343.
Junko Takashima 1,  Yoshitaka Ikeda,  Kanki Komiyama,  Masahiko Hayashi,  Akio Kishida,  Ayumi Ohsaki
Affiliations

Affiliation

  • 1 Pharmaceuticals Research Division, Mitsubishi Pharma Corporation, Yokohama, Japan. Takashima.Junko@me.m-pharma.co.jp
PMID: 17268114 DOI: 10.1248/cpb.55.343
Abstract

A new iridoid glycoside, citrifoside (1), and a new anthraquinone, 1,5,15-trimethylmorindol (2), together with 24 known compounds, were isolated from the leaves of Morinda citrifolia. The structures of the new compounds were elucidated by spectral data. 1,5,15-Trimethylmorindol (2) did not show significant cytotoxic activity by itself but showed cytotoxicity when combined with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), while citrifoside (1) did not show any activity even with TRAIL.

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