2. Academic Validation
  3. Cytotoxic diterpenoids from the bark of Pseudolarix kaempferi and their structure-activity relationships

Cytotoxic diterpenoids from the bark of Pseudolarix kaempferi and their structure-activity relationships

  • J Nat Prod. 2007 Apr;70(4):533-7. doi: 10.1021/np060439q.
Peng Liu 1,  Hongzhu Guo,  Weixing Wang,  Jie Zhang,  Na Li,  Jian Han,  Jianping Zhou,  Yuchi Hu,  Tong Zhang,  Zhenming Liu,  Dean Guo
Affiliations

Affiliation

  • 1 Division of Pharmacognostical Biotechnology, School of Pharmaceutical Sciences, Peking University, Xueyuan Road 38, Beijing 100083, People's Republic of China.
PMID: 17291040 DOI: 10.1021/np060439q
Abstract

Four new Diterpenoids, 11S-deacetylpseudolaric acid A (2), deacetylpseudolaric acid A O-beta-d-glucopyranoside (3), deacetylpseudolaric acid A 2,3-dihydroxypropyl ester (4), and deacetylpseudolaric acid B 2,3-dihydroxypropyl ester (5), and nine known Diterpenoids were isolated from the bark of Pseudolarix kaempferi. Their structures were determined on the basis of chemical and spectroscopic analyses. In addition, their in vitro cytotoxic activities against three human Cancer cell lines and their structure-activity relationships were evaluated.

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