2. Academic Validation
  3. Discovery of tertiary aminoacids as dual PPARalpha/gamma agonists-I

Discovery of tertiary aminoacids as dual PPARalpha/gamma agonists-I

  • Bioorg Med Chem Lett. 2007 Apr 15;17(8):2312-6. doi: 10.1016/j.bmcl.2007.01.060.
Pratik V Devasthale 1,  Sean Chen,  Yoon Jeon,  Fucheng Qu,  Denis E Ryono,  Wei Wang,  Hao Zhang,  Lin Cheng,  Dennis Farrelly,  Rajasree Golla,  Gary Grover,  Zhengping Ma,  Lisa Moore,  Ramakrishna Seethala,  Wei Sun,  Arthur M Doweyko,  Gamini Chandrasena,  Paul Sleph,  Narayanan Hariharan,  Peter T W Cheng
Affiliations

Affiliation

  • 1 Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, PO Box 5400, Princeton, NJ 08543-5400, USA. pratik.devasthale@bms.com
PMID: 17292606 DOI: 10.1016/j.bmcl.2007.01.060
Abstract

A novel series of potent dual agonists of PPARalpha and PPARgamma, the alkoxybenzylglycines, was identified and explored using a solution-phase library approach. The synthesis and structure-activity relationships of this series of dual PPARalpha/gamma agonists are described.

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