2. Academic Validation
  3. Synthesis and antibacterial activity of levofloxacin derivatives with certain bulky residues on piperazine ring

Synthesis and antibacterial activity of levofloxacin derivatives with certain bulky residues on piperazine ring

  • Eur J Med Chem. 2007 Jul;42(7):985-92. doi: 10.1016/j.ejmech.2006.12.034.
Alireza Foroumadi 1,  Saeed Emami,  Shahla Mansouri,  Azita Javidnia,  Nosratollah Saeid-Adeli,  Farshad H Shirazi,  Abbas Shafiee
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran.
PMID: 17316916 DOI: 10.1016/j.ejmech.2006.12.034
Abstract

A number of levofloxacin analogues carrying a 2-aryl-2-oxoethyl or a 2-aryl-2-oxyiminoethyl moiety attached to the piperazine ring at C-10 position have been prepared and evaluated as Antibacterial agents against a series of Gram-positive and Gram-negative bacteria. Some of them exhibited significant inhibitory activity against Gram-positive bacteria.

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