2. Academic Validation
  3. Design, synthesis, and evaluation of the antiproliferative activity of a series of novel fused xanthenone aminoderivatives in human breast cancer cells

Design, synthesis, and evaluation of the antiproliferative activity of a series of novel fused xanthenone aminoderivatives in human breast cancer cells

  • J Med Chem. 2007 Apr 5;50(7):1716-9. doi: 10.1021/jm061410m.
Vasiliki Giannouli 1,  Ioannis K Kostakis,  Nicole Pouli,  Panagiotis Marakos,  Olga Ch Kousidou,  George N Tzanakakis,  Nikos K Karamanos
Affiliations

Affiliation

  • 1 Department of Pharmacy, Division of Pharmaceutical Chemistry, University of Athens, Panepistimiopolis-Zografou, Athens 15771, Greece.
PMID: 17335189 DOI: 10.1021/jm061410m
Abstract

Derivatives of two novel, structurally related heterocyclic ring systems, xantheno[3,4-d]imidazole and chromeno[4,3,2-c,d]imidazo[4,5-f]indazole, bearing aminoalkyl side chains, have been synthesized, and their antiproliferative activity has been studied against the aggressive human breast MDA-MB-231 cell line. The pyrazole-fused analogue 27a possesses a pronounced antiproliferative effect on the tested cell line, evident at 1 muM, and achieves an IC50 of 6.5 microM.

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