2. Academic Validation
  3. Imidazo[1,2-a]pyridines with potent activity against herpesviruses

Imidazo[1,2-a]pyridines with potent activity against herpesviruses

  • Bioorg Med Chem Lett. 2007 May 15;17(10):2735-9. doi: 10.1016/j.bmcl.2007.02.079.
Kristjan S Gudmundsson 1,  Brian A Johns
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Infectious Diseases Center of Excellence for Drug Discovery, GlaxoSmithKline Research & Development, Five Moore Drive, Research Triangle Park, NC 27709-3398, USA. Kristjan.S.Gudmundsson@gsk.com
PMID: 17368024 DOI: 10.1016/j.bmcl.2007.02.079
Abstract

Synthesis of a series of 2-aryl-3-pyrimidyl-imidazo[1,2-a]pyridines with potent activity against herpes simplex viruses is described. Synthetic approaches allowing for variation of the 2-aryl, 3-heteroaryl as well as Other imidazopyridine substituents are outlined and resulting effects on Antiviral activity are highlighted. Several compounds with in vitro Antiviral activity similar or better than acyclovir are described.

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