2. Academic Validation
  3. Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines

Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines

  • Bioorg Med Chem. 2007 May 15;15(10):3381-9. doi: 10.1016/j.bmc.2007.03.021.
Shiming Li 1,  Min-Hsiung Pan,  Ching-Shu Lai,  Chih-Yu Lo,  Slavik Dushenkov,  Chi-Tang Ho
Affiliations

Affiliation

  • 1 Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901-8520, USA. shiming.li@roche.com
PMID: 17391969 DOI: 10.1016/j.bmc.2007.03.021
Abstract

Fifteen polymethoxyflavones (PMFs) and hydroxylated PMFs were isolated from sweet orange (Citrus sinensis) peel extract and synthesized to investigate their biological activity. All obtained compounds were tested in HL-60 Cancer cell proliferation and Apoptosis induction assays. While some PMFs and hydroxylated PMFs had moderate anti-carcinogenic activities, 5-hydroxy-6,7,8,3',4'-pentamethoxyflavone and 5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone showed strong inhibitory activities against the proliferation and induced Apoptosis of HL-60 cell lines.

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