2. Academic Validation
  3. The novel MGC13096 protein is correlated with proliferation

The novel MGC13096 protein is correlated with proliferation

  • Cell Biochem Funct. 2008 Mar-Apr;26(2):141-5. doi: 10.1002/cbf.1410.
Qiu Chen 1,  Chengqi Yan,  Qingfeng Yan,  Lifeng Feng,  Jianping Chen,  Kaixian Qian
Affiliations

Affiliation

  • 1 College of Life Sciences, Zhejiang University, Hangzhou, PR China.
PMID: 17393540 DOI: 10.1002/cbf.1410
Abstract

We report a functional characterisation of the novel protein MGC13096. MGC13096 over-expression restrained proliferation of HEK293T cells. DNA/flow cytometry analysis showed that the over-expression of MGC13096 severely delays cell cycle progression at S phase. Transcription factors such as activator protein-1 (AP-1), cAMP response element binding protein (CREB), nuclear factor of activated T cells (NFAT), NF-kappaB, signal transducer and activator of transcription 1 (STAT1) took part in the process.

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