2. Academic Validation
  3. PIN1, the cell cycle and cancer

PIN1, the cell cycle and cancer

  • Nat Rev Cancer. 2007 May;7(5):381-8. doi: 10.1038/nrc2107.
Elizabeth S Yeh 1,  Anthony R Means
Affiliations

Affiliation

  • 1 Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, 421 Curie Boulevard, Philadelphia, PA 19104-6160, USA.
PMID: 17410202 DOI: 10.1038/nrc2107
Abstract

PIN1 is a peptidyl-prolyl isomerase that can alter the conformation of phosphoproteins and so affect protein function and/or stability. PIN1 regulates a number of proteins important for cell-cycle progression and, based on gain- and loss-of-function studies, is presumed to operate as a molecular timer of this important process. Therefore, it seems logical that alterations in the level of PIN1 can influence hyperproliferative diseases such as Cancer. However, the precise role of PIN1 in Cancer remains controversial.

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