Cytotoxic withanolides from Tubocapsicum anomalum

J Nat Prod. 2007 May;70(5):747-53. doi: 10.1021/np0605541.

Pei-Wen Hsieh ¹, Zih-You Huang, Jyun-Hong Chen, Fang-Rong Chang, Ching-Chung Wu, Yu-Liang Yang, Michael Y Chiang, Ming-Hon Yen, Shu-Li Chen, Hsin-Fu Yen, Tilo Lübken, Wen-Chun Hung, Yang-Chang Wu

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Affiliation

1 Graduate Institute of Natural Products, School of Pharmcy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.

PMID: 17417907 DOI: 10.1021/np0605541

Abstract

Fifteen new withanolides (1-8, 11-17) and two known withanolides, withanolide D (9) and 17alpha-hydroxywithanolide D (10), were isolated from the stems, roots, and leaves of Tubocapsicum anomalum using bioassay-directed fractionation. The structures were determined by spectroscopic and chemical methods, and the absolute configurations were established by CD analysis and by the Mosher ester method. The structure of 1 and 3 were further confirmed by X-ray crystallographic analysis. Compounds 1, 4-6, 8-10, and 13 showed significant cytotoxic activity against Hep G2, Hep 3B, A-549, MDA-MB-231, MCF-7, and MRC-5 cell lines.

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