2. Academic Validation
  3. Concise synthesis of dideoxy-epigallocatechin gallate (DO-EGCG) and evaluation of its anti-influenza virus activity

Concise synthesis of dideoxy-epigallocatechin gallate (DO-EGCG) and evaluation of its anti-influenza virus activity

  • Bioorg Med Chem Lett. 2007 Jun 1;17(11):3095-8. doi: 10.1016/j.bmcl.2007.03.041.
Takumi Furuta 1,  Yasuo Hirooka,  Ayako Abe,  Yusuke Sugata,  Mitsuru Ueda,  Kouki Murakami,  Takashi Suzuki,  Kiyoshi Tanaka,  Toshiyuki Kan
Affiliations

Affiliation

  • 1 Department of Synthetic Organic & Medicinal Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan. furuta@u-shizuoka-ken.ac.jp
PMID: 17420124 DOI: 10.1016/j.bmcl.2007.03.041
Abstract

Dideoxy-epigallocatechin gallate (DO-EGCG) (2), a simplified analog of naturally occurring EGCG (1), was efficiently prepared by directly introducing a ketone group at C3 and successive reduction to the sec-alcohol with 2,3-cis stereochemistry. Compound 2 showed potent anti-influenza virus activity, indicating that the hydroxyl substituents on the A-ring are not crucial for anti-influenza virus activity.

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