2. Academic Validation
  3. Farnesyl protein transferase and tumor cell growth inhibitory activities of lipiferolide isolated from Liriodendron tulipifera

Farnesyl protein transferase and tumor cell growth inhibitory activities of lipiferolide isolated from Liriodendron tulipifera

  • Arch Pharm Res. 2007 Mar;30(3):299-302. doi: 10.1007/BF02977609.
Mi Kyeong Moon 1,  Hyun Mi Oh,  Byoung-Mog Kwon,  Nam-In Baek,  Sung-Hoon Kim,  Ju Sin Kim,  Dae Keun Kim
Affiliations

Affiliation

  • 1 College of Pharmacy, Woosuk University, Samrye 565-701, Korea.
PMID: 17424934 DOI: 10.1007/BF02977609
Abstract

The methanolic extract of the leaves of Liriodendron tulipifera was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of lipiferolide, an inhibitor of FPTase. This compound inhibited the FPTase activity in a dose-dependent manner, and showed cell growth inhibitory activity against several tumor cells.

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