2. Academic Validation
  3. Bridged androstenediol analogs as ER-beta selective SERMs

Bridged androstenediol analogs as ER-beta selective SERMs

  • Bioorg Med Chem Lett. 2007 May 15;17(10):2944-8. doi: 10.1016/j.bmcl.2006.12.053.
Timothy A Blizzard 1,  Candido Gude,  Wanda Chan,  Elizabeth T Birzin,  Marina Mojena,  Consuelo Tudela,  Fang Chen,  Kristin Knecht,  Qin Su,  Bryan Kraker,  Mark A Holmes,  Susan P Rohrer,  Milton L Hammond
Affiliations

Affiliation

  • 1 Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA. tim_blizzard@merck.com
PMID: 17448656 DOI: 10.1016/j.bmcl.2006.12.053
Abstract

A series of bridged androstenediol derivatives was prepared. The bridged compounds exhibited reduced ER-beta selectivity relative to uncyclized analogs.

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