2. Academic Validation
  3. Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates

Selective inhibition of porcine endogenous retrovirus replication in human cells by acyclic nucleoside phosphonates

  • Antimicrob Agents Chemother. 2007 Jul;51(7):2600-4. doi: 10.1128/AAC.00212-07.
Minyi Shi 1,  Xin Wang,  Erik De Clercq,  Sonshin Takao,  Masanori Baba
Affiliations

Affiliation

  • 1 Frontier Science Research Center, Kagoshima University, Kagoshima 890-8544, Japan.
PMID: 17470654 DOI: 10.1128/AAC.00212-07
Abstract

Several anti-human immunodeficiency virus type 1 Reverse Transcriptase inhibitors were evaluated for their Antiviral activities against porcine endogenous retrovirus in human cells. Among the test compounds, zidovudine was found to be the most active. The order of potency was zidovudine > phosphonylmethoxyethoxydiaminopyrimidine = phosphonylmethoxypropyldiaminopurine > tenofovir > or = adefovir > stavudine.

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