2. Academic Validation
  3. Molecular design, chemical synthesis, and biological evaluation of '4-1' pentacyclic aryl/heteroaryl-imidazonaphthalimides

Molecular design, chemical synthesis, and biological evaluation of '4-1' pentacyclic aryl/heteroaryl-imidazonaphthalimides

  • Bioorg Med Chem. 2007 Aug 1;15(15):5114-21. doi: 10.1016/j.bmc.2007.05.032.
Feng Li 1,  Jingnan Cui,  Lianying Guo,  Xuhong Qian,  Weimin Ren,  Kewei Wang,  Fengyu Liu
Affiliations

Affiliation

  • 1 State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian, China.
PMID: 17532640 DOI: 10.1016/j.bmc.2007.05.032
Abstract

A novel series of '4-1' pentacyclic naphthalimides, where the chromophore consists of a naphthalimide moiety, fused to an imidazole ring containing an unfused aryl or heteroaryl ring, were synthesized and evaluated for in vitro antitumor activity. In general, the new derivatives showed an improved cytotoxic activity over amonafide. DNA binding experiments supported that this class of compounds behaves as effective DNA-intercalating agents.

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