2. Academic Validation
  3. Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators

Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators

  • Bioorg Med Chem Lett. 2007 Aug 15;17(16):4487-90. doi: 10.1016/j.bmcl.2007.06.007.
Mark C Manfredi 1,  Yingzhi Bi,  Alexandra A Nirschl,  James C Sutton,  Ramakrishna Seethala,  Rajasree Golla,  Blake C Beehler,  Paul G Sleph,  Gary J Grover,  Jacek Ostrowski,  Lawrence G Hamann
Affiliations

Affiliation

  • 1 Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000, USA. mark.manfredi@bms.com
PMID: 17574413 DOI: 10.1016/j.bmcl.2007.06.007
Abstract

Replacement of the 3-oxo group of 2-chloro-4-[(7R,7aS)-7-hydroxy-1,3-dioxotetrahydro-1H-pyrrolo[1,2c]imidazol-2(3H)-yl]-3-methylbenzonitrile resulted in a sulfamide series of selective Androgen Receptor modulator (SARM) agonists.

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