2. Academic Validation
  3. Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe

Cyclic depsipeptides, ichthyopeptins A and B, from Microcystis ichthyoblabe

  • J Nat Prod. 2007 Jul;70(7):1084-8. doi: 10.1021/np060303s.
Elmi N Zainuddin 1,  Renate Mentel,  Victor Wray,  Rolf Jansen,  Manfred Nimtz,  Michael Lalk,  Sabine Mundt
Affiliations

Affiliation

  • 1 Institute of Pharmacy, Friedrich-Ludwig-Jahnstrasse 17, Ernst-Moritz-Arndt University, D-17487 Greifswald, Germany.
PMID: 17602586 DOI: 10.1021/np060303s
Abstract

Bioassay-guided isolation of Antiviral compounds from the cultured cyanobacterium Microcystis ichthyoblabe provided two novel cyclic depsipeptides, ichthyopeptins A (1) and B (2). Their structures were determined by 1D (1H and 13C) and 2D (COSY, TOCSY, ROESY, HMQC, and HMBC) NMR spectra, ESIMS-MS, and amino acid analysis. The fraction containing both cyclic depsipeptides exhibited Antiviral activity against influenza A virus with an IC50 value of 12.5 microg/mL.

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