2. Academic Validation
  3. Synthesis of ferulic ester dimers, functionalisation and biological evaluation as potential antiatherogenic and antiplasmodial agents

Synthesis of ferulic ester dimers, functionalisation and biological evaluation as potential antiatherogenic and antiplasmodial agents

  • Bioorg Med Chem. 2007 Sep 15;15(18):6018-26. doi: 10.1016/j.bmc.2007.06.047.
D L A Rakotondramanana 1,  Mélanie Delomenède,  Michel Baltas,  Hubert Duran,  Florence Bedos-Belval,  Philippe Rasoanaivo,  Anne Negre-Salvayre,  Heinz Gornitzka
Affiliations

Affiliation

  • 1 Laboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique, LSPCMIB, UMR-CNRS 5068, Université Paul Sabatier, 118, Route de Narbonne, 31062 Toulouse Cedex 9, France.
PMID: 17624792 DOI: 10.1016/j.bmc.2007.06.047
Abstract

Oxidative dimerization of ferulic acid methyl ester afforded dihydrobenzofuran derivative and new linear compound identified by X-ray crystallography. The gallate derivatized dihydrobenzofuran analogue was obtained and all compounds were evaluated for potential antiatherogenic, antiplasmodial (best IC(50)=0.8 microM) and cytotoxic activities.

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