2. Academic Validation
  3. Second generation of alpha-tocopherol analogs-nitric oxide donors: Synthesis, physicochemical, and biological characterization

Second generation of alpha-tocopherol analogs-nitric oxide donors: Synthesis, physicochemical, and biological characterization

  • Bioorg Med Chem. 2007 Sep 15;15(18):6262-72. doi: 10.1016/j.bmc.2007.06.019.
Gloria V López 1,  Fabiana Blanco,  Paola Hernández,  Ana Ferreira,  Oscar E Piro,  Carlos Batthyány,  Mercedes González,  Homero Rubbo,  Hugo Cerecetto
Affiliations

Affiliation

  • 1 Departamento de Química Orgánica, Facultad de Ciencias-Facultad de Química Universidad de la República, Montevideo, Uruguay.
PMID: 17627828 DOI: 10.1016/j.bmc.2007.06.019
Abstract

Synthesis, physicochemical, and biological characterization of a series of alpha-tocopherol mimetics with NO-releasing capacity are reported. The selected NO-donor moieties were nitrooxy and furoxan. All products were tested for their in vitro NO-releasing capacities, vasodilating properties and mammal cytotoxic activities. The lipophilic-hydrophilic balance of all products was also evaluated. A new hybrid furoxan, phenol derivative 17, possesses adequate profile of the studied properties.

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