2. Academic Validation
  3. Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus

Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus

  • J Nat Prod. 2007 Aug;70(8):1263-7. doi: 10.1021/np070138w.
Li-Bo Zhou 1,  Tzu-Hsuan Chen,  Kenneth F Bastow,  Makio Shibano,  Kuo-Hsiung Lee,  Dao-Feng Chen
Affiliations

Affiliation

  • 1 Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 200032, People's Republic of China.
PMID: 17629328 DOI: 10.1021/np070138w
Abstract

Four new steroidal saponins, filiasparosides A-D (1-4), together with known aspafiliosides A (5) and B (6) were isolated from the roots of Asparagus filicinus. The structures of these new compounds were elucidated by detailed spectroscopic study and chemical analysis. Compounds 1-6 were cytotoxic against human lung carcinoma (A549) and breast adenocarcinoma (MCF-7) tumor cell lines with EC(50) values of 2.3-16.8 microg/mL. Compound 3 showed the most potent cytotoxicity, with EC(50) values of 2.3 and 3.0 microg/mL toward A549 and MCF-7 cell lines, respectively.

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