2. Academic Validation
  3. Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera

Pomiferin, histone deacetylase inhibitor isolated from the fruits of Maclura pomifera

  • Bioorg Med Chem Lett. 2007 Sep 1;17(17):4753-5. doi: 10.1016/j.bmcl.2007.06.060.
Il Hong Son 1,  Ill-Min Chung,  Sung Ik Lee,  Hyun Duk Yang,  Hyung-In Moon
Affiliations

Affiliation

  • 1 Department of Neuroscience, Inam Neuroscience Research Center, Sanbon Medical Center, Wonkwang University, Gunpo-City, Kyunggido, South Korea.
PMID: 17662606 DOI: 10.1016/j.bmcl.2007.06.060
Abstract

The major constituents from the fruits of Maclura pomifera are the prenylated Isoflavones, osajin (1) and pomiferin (2). Their structures were elucidated using NMR spectroscopic techniques and mass spectrometric analysis. Compound 2 showed potential inhibitory activity in histone deacetylase (HDAC) Enzyme assay. It also exhibited growth inhibitory activity on five human tumor cell lines and more sensitive inhibitory activity on the HCT-15 colon tumor cell line. Further structure-activity relationships of position 3 on ring B from aromatic ring will be reported in due course.

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