2. Academic Validation
  3. Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens

Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens

  • Antimicrob Agents Chemother. 2007 Nov;51(11):4160-2. doi: 10.1128/AAC.00736-07.
Sunwen Chou 1,  Gail I Marousek,  Laura C Van Wechel,  Shaobing Li,  Adriana Weinberg
Affiliations

Affiliation

  • 1 Divisionof Infectious Disease, Oregon Health Science University, VA Medical Center, Portland, OR 97239, USA. chous@ohsu.edu
PMID: 17709468 DOI: 10.1128/AAC.00736-07
Abstract

Recombinant phenotyping of cytomegalovirus (CMV) pol region III mutations from clinical specimens showed that T813S and G841A each conferred foscarnet resistance and approximately threefold increased ganciclovir resistance; adding the UL97 mutation C592G increased ganciclovir resistance to approximately sixfold. Bacterial artificial chromosome CMV clones containing pol mutation L845P were nonviable unless repaired with the wild-type sequence.

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