2. Academic Validation
  3. Synthesis of new 7-chloroquinolinyl thioureas and their biological investigation as potential antimalarial and anticancer agents

Synthesis of new 7-chloroquinolinyl thioureas and their biological investigation as potential antimalarial and anticancer agents

  • Bioorg Med Chem Lett. 2007 Oct 15;17(20):5683-5. doi: 10.1016/j.bmcl.2007.07.049.
Aman Mahajan 1,  Susan Yeh,  Margo Nell,  Constance E J van Rensburg,  Kelly Chibale
Affiliations

Affiliation

  • 1 Department of Chemistry, University of Cape Town, Private Bag, Rondebosh 7701, South Africa.
PMID: 17768052 DOI: 10.1016/j.bmcl.2007.07.049
Abstract

New 7-chloroquinolinyl thiourea derivatives derived from the corresponding 4,7-dichloroquinoline isothiocyanate were synthesized and evaluated for in vitro antimalarial and Anticancer activity. The most active compound from the series displayed an inhibitory IC(50) value of 1.2 microM against the D10 strain of Plasmodium falciparum. Lack of cytotoxicity towards HeLa cells indicates selectivity towards parasites.

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