2. Academic Validation
  3. Hemoglobin Rainier (beta145 Tyrosine rarr Histidine): Alkali-Resistant Hemoglobin with Increased Oxygen Affinity

Hemoglobin Rainier (beta145 Tyrosine rarr Histidine): Alkali-Resistant Hemoglobin with Increased Oxygen Affinity

  • Science. 1968 Feb 16;159(3816):741-3. doi: 10.1126/science.159.3816.741.
G Stamatoyannopoulos,  A Yoshida,  J Adamson,  S Heinenberg
PMID: 17795074 DOI: 10.1126/science.159.3816.741
Abstract

Hemoglobin Rainier, a new hemoglobin variant associated with erythrocytosis, was found in six members of a Caucasiant family. Structurally, it represents substitution of histidine for the invariant residute H23 tyrosine in the beta-hemoglobin polypeptide chain (beta(145) tyrosine --> histidine). Hemoglobin Rainier is the first example of a single amino acid substitution in adult human hemoglobin, causing increased resistance to alkali denaturation.

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