2. Academic Validation
  3. Synthesis, DNA binding, and cytotoxicity studies of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates

Synthesis, DNA binding, and cytotoxicity studies of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates

  • Bioorg Med Chem. 2007 Nov 15;15(22):6868-75. doi: 10.1016/j.bmc.2007.08.026.
Ahmed Kamal 1,  R Ramu,  Venkatesh Tekumalla,  G B Ramesh Khanna,  Madan S Barkume,  Aarti S Juvekar,  Surekha M Zingde
Affiliations

Affiliation

  • 1 Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India. ahmedkamal@iict.res.in
PMID: 17822905 DOI: 10.1016/j.bmc.2007.08.026
Abstract

A series of pyrrolo[2,1-c][1,4]benzodiazepine-anthraquinone conjugates have been prepared and evaluated for their DNA binding ability as well as Anticancer activity. Some of these molecules have shown significant Anticancer activity in a number of Cancer cell lines.

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