2. Academic Validation
  3. Discovery of potent T-type calcium channel blocker

Discovery of potent T-type calcium channel blocker

  • Bioorg Med Chem Lett. 2007 Nov 1;17(21):5740-3. doi: 10.1016/j.bmcl.2007.08.070.
Han Na Seo 1,  Ja Youn Choi,  Yun Jeong Choe,  Yoonjee Kim,  Hyewhon Rhim,  So Ha Lee,  Jungahn Kim,  Dong Jun Joo,  Jae Yeol Lee
Affiliations

Affiliation

  • 1 Research Institute for Basic Sciences and Department of Chemistry, Kyung Hee University, Seoul 130-701, Republic of Korea.
PMID: 17869104 DOI: 10.1016/j.bmcl.2007.08.070
Abstract

The intensive SAR study of 3,4-dihydroquinazoline series led to the most potent compound 10 (KYS05090: IC(50)=41+/-1 nM) against T-type calcium channel and its potency is nearly comparable to that of Kurtoxin. As a small organic molecule, this compound showed the highest blocking activity reported to date.

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