2. Academic Validation
  3. Some new acyclic nucleotide analogues as antiviral prodrugs: synthesis and bioactivities in vitro

Some new acyclic nucleotide analogues as antiviral prodrugs: synthesis and bioactivities in vitro

  • Bioorg Med Chem Lett. 2007 Nov 15;17(22):6350-3. doi: 10.1016/j.bmcl.2007.08.065.
Yan-bo Tang 1,  Zong-gen Peng,  Zong-ying Liu,  Yan-ping Li,  Jian-dong Jiang,  Zhuo-rong Li
Affiliations

Affiliation

  • 1 Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China.
PMID: 17888662 DOI: 10.1016/j.bmcl.2007.08.065
Abstract

A series of ester analogues of acyclic nucleotide PMPA and PMEA were synthesized as potent Antiviral agents. The Antiviral evaluation results indicated that bis benzyl ester prodrug of PMPA 5f and bis allyl ester prodrug of PMEA 5g exhibited potent Antiviral activities. The IC(50) of 5f for HBV was 2.15 microM, and the IC(50) of 5g for HIV-1 was 1.61 microM.

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