2. Academic Validation
  3. New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation

New 'chemical probes' to examine the role of the hFPRL1 (or ALXR) receptor in inflammation

  • Bioorg Med Chem Lett. 2007 Dec 1;17(23):6633-7. doi: 10.1016/j.bmcl.2007.09.043.
Mike Frohn 1,  Han Xu,  Xiaoming Zou,  Catherine Chang,  Michele McElvaine,  Matthew H Plant,  Min Wong,  Philip Tagari,  Randall Hungate,  Roland W Bürli
Affiliations

Affiliation

  • 1 Chemistry Research and Discovery, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA. mfrohn@amgen.com
PMID: 17920884 DOI: 10.1016/j.bmcl.2007.09.043
Abstract

We report the development of the novel N-substituted benzimidazole 11 as a potent and selective human formyl peptide receptor-like 1 (hFPRL1) agonist. This compound and its less active enantiomer 12 were identified as useful tools for studying receptor function in vitro.

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