2. Academic Validation
  3. Synthesis and biological activities of a series of 4,5-diaryl-3-hydroxy-2(5H)-furanones

Synthesis and biological activities of a series of 4,5-diaryl-3-hydroxy-2(5H)-furanones

  • Eur J Med Chem. 2008 Jun;43(6):1222-9. doi: 10.1016/j.ejmech.2007.08.005.
Fabrice Bailly 1,  Clémence Queffélec,  Gladys Mbemba,  Jean-François Mouscadet,  Nicole Pommery,  Jean Pommery,  Jean-Pierre Hénichart,  Philippe Cotelle
Affiliations

Affiliation

  • 1 Laboratoire de Chimie Organique et Macromoléculaire, UMR CNRS 8009, Bâtiment C3, Université de Lille 1, 59655 Villeneuve d'Ascq Cedex, France.
PMID: 17937972 DOI: 10.1016/j.ejmech.2007.08.005
Abstract

A series of thirteen 4,5-diaryl-3-hydroxy-2(5H)-furanones were synthesized. They were evaluated for their antioxidant potencies and inhibitory properties of 5-lipoxygenase, cyclooxygenases, HIV-1 integrase and PC3 cell proliferation. New hits were discovered either in the anti-proliferation test or in the HIV anti-integrase test.

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